HYPOGLYCEMIC AND ANTI-LIPIDEMIC EFFECTS OF HYDRO- ETHANOLIC EXTRACT OF CEIBA PENTANDRA Linn

The hypoglycemic and anti-lipidemic effect of hydro-ethanolic extract of Ceiba pentandra Linn (FamilySterculiaceae) root extracts (CPE) were investigated in normal and alloxan-induced diabetic rats. In the present study, the animals were divided into normal control, diabetic control, diabetic treated and control treated group (n = 6). Effect of oral administration of CPE (300 mg/kg) for 30 days on the level of blood glucose, glycosylated haemoglobin (HbA1C), total cholesterol (TC), triglycerides (TG), phospholipids, low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), hexokinase, lactate dehydrogenase (LDH) and glucose-6-phosphatase in normal and alloxan-induced diabetic rats were evaluated. When comparing the values of the CPE treated group with those of the control diabetic group, we found that the CPE significantly decreased the elevated blood glucose level, glycosylated haemoglobin, cholesterol, triglycerides, phospholipids, LDL, VLDL. It showed a significant increase in liver glycogen, insulin and HDL level. Treatment with CPE in diabetic rats increased the hexokinase, LDH activity and decreased the glucose-6-phosphatase activity. These results clearly indicated that CPE possess promising anti-diabetic effect in diabetic rats.